Drug-Supplement Interactions Database

5-HTP (4) 5-HTP (5-Hydroxytryptophan) (4) Acacia Fiber (2) ACE Inhibitors (Lisinopril/Enalapril) (1) ACE Inhibitors (Lisinopril/Ramipril) (1) ACE2 enzyme (oral supplement) (2) ACE2/Angiotensin 1-7 (oral bioencapsulated supplement) (2) Acetyl L-Carnitine (3) Alcohol (3) Alcohol (Ethanol) (3) Alpha Lipoic Acid (2) Alpha Lipoic Acid (ALA) (1) Alpha-Lipoic Acid (ALA) (2) Aluminum (antacids/supplements) (1) Aluminum Hydroxide (Antacid) (1) Aluminum-containing antacids (1) Amiodarone (high iodine content cardiac drug) (1) Amoxicillin (1) Angiotensin 1-7 (Ang1-7) supplement (1) Anticoagulants/Antiplatelet Drugs (1) Antihypertensive medications (e.g., ACE inhibitors, ARBs) (1) Antihypertensives (Multiple Classes) (1) Antioxidant Combination (Vitamins C + E + Beta-Carotene) (1) antioxidant supplements (polyphenols, vitamins, carotenoids) (1) Arnica (2) Arsenic sulfide-containing TCM formulations (1) Ashwagandha (6) Asian Ginseng (1) Astaxanthin (6) Bacillus coagulans (1) Bacopa Monnieri (6) Bentonite Clay (1) Benzodiazepines (e.g., Lorazepam, Clonazepam) (1) Benzodiazepines / CNS Depressants (1) Berberine (70) Bergamot Extract (BPF) (1) Beta-Blockers (Metoprolol/Atenolol) (1) Bifidobacterium animalis (1) Bifidobacterium longum (1) Bilberry (6) Biotin (6) Biotin (Vitamin B7) (2) Bismuth subsalicylate (1) Bismuth Subsalicylate (Pepto-Bismol) (1) Black Cohosh (2) Blood Pressure Medications (1) Boron (4) Boswellia (1) Botanical (Herbal) Products (general) (1) Bromelain (6) Caffeine (8) Caffeine (energy supplements) (1) Caffeine (high-dose energy supplements) (1) Caffeine (High-Dose Supplements) (1) Calcium (29) Calcium (antacids/supplements) (1) Calcium (Calcium Carbonate) (2) Calcium (intravenous) (1) Calcium (oral supplements) (1) Calcium Carbonate (2) Calcium Carbonate (Antacid) (1) Calcium Carbonate / Antacids (1) Calcium Channel Blockers (Amlodipine/Verapamil) (1) Calcium Citrate (1) Calcium supplement (2) Calcium-containing antacids (1) Cannabidiol (CBD) (2) Cannabidiol (CBD) Oral Solution (1) Capsaicin (1) Centella asiatica (gotu kola) (1) Cetirizine (1) Chaga (Inonotus obliquus) (2) Chan Su (1) Chlorella (2) Chromium (6) Chromium (Chromium Picolinate / Chromium GTF) (1) Chromium Picolinate (2) Cigarette Smoking (Tobacco) (1) Cinnamon (2) Cinnamon (Cinnamomum cassia/verum) (1) CLA (Conjugated Linoleic Acid) (2) Coenzyme Q10 (CoQ10 / Ubiquinol) (1) Coenzyme Q10 (CoQ10) (3) Collagen (4) Collagen Peptides (1) Collagen Peptides (hydrolyzed collagen protein) (1) Conjugated Linoleic Acid (1) Copper (2) Copper Bisglycinate (3) Copper supplement (2) Copper Supplements (1) CoQ10 (13) CoQ10 (Ubiquinol) (1) CoQ10 (Ubiquinone) (7) CoQ10 Ubiquinol (1) Cordyceps (Cordyceps sinensis/militaris) (2) Cottonseed Meal (1) cranberry juice / cranberry supplements (2) Creatine (2) Creatine Monohydrate (2) Curcumin (62) Curcumin (Turmeric) (2) Dairy Products (1) Dandelion Root (2) Dashen (Danshen) (1) Devils Claw (4) DHA (Docosahexaenoic Acid) (2) DHEA (5) Dietary Fiber (1) Digestive Enzymes (1) Digestive Enzymes (lipase, amylase, protease blends) (1) Digestive Enzymes (lipase, protease, amylase blends) (1) Diphenhydramine (1) Diuretics (Furosemide/Hydrochlorothiazide) (1) Echinacea (61) EGCG Green Tea (3) Eicosapentaenoic acid/Docosahexaenoic acid (EPA/DHA) supplement (1) Electrolytes (sodium, potassium, magnesium) (1) EPA (Eicosapentaenoic Acid) (4) EPA/DHA (Eicosapentaenoic acid / Docosahexaenoic acid supplement) (1) Ephedra/Ma Huang (1) Ergothioneine (1) Evening Primrose Oil (3) Fat-soluble vitamins (A, D, E, K) (1) Fexofenadine (1) Fiber (Psyllium / Glucomannan) (1) Fiber (Psyllium Husk, Glucomannan) (1) Fisetin (1) Fish Oil (6) Fish Oil (Cod Liver Oil) (1) Fish Oil (Omega-3 / EPA/DHA) (1) Fish Oil (Omega-3 EPA/DHA) (1) Fish Oil (Omega-3) (1) Fish Oil / Krill Oil (Omega-3) (1) folate (1) Folate (2) Folate (5-MTHF / Methylfolate) (1) Folate (Folic Acid / L-Methylfolate) (1) Folate (Folic Acid / Methylfolate) (2) Folate (L-Methylfolate) (1) Folate (Methylfolate 5-MTHF) (1) Folate (Methylfolate) (3) Folate (Vitamin B9) (5) Folic Acid (5) Folic Acid (Folate) (1) Folic Acid (High-dose) (1) Folinic Acid (Leucovorin) (1) Food (general) (1) FOS (2) Fucus vesiculosus (bladderwrack) (1) Garlic (2) Garlic Extract (49) Ginger (Zingiber officinale) (1) Ginkgo (3) Ginkgo biloba (10) Ginkgo Biloba (58) Ginkgo biloba extract (1) Ginseng (4) GLA Evening Primrose Oil (2) Glucomannan (2) Glutamine (1) Glutathione (2) Glycine (2) Goldenseal (63) Gotu Kola (2) Grapefruit (38) Grapefruit / Grapefruit Juice (3) Grapefruit Juice (16) Green Coffee Extract (5) Hawthorn (4) Hepatotoxic Medications (1) Herbal supplements (general) (1) Histamine-containing foods (skipjack, tuna, tropical fish) (1) Huperzine A (3) Hyaluronic Acid (2) Insulin (exogenous) or Insulin Secretagogues (Sulfonylureas) (1) Inulin (4) Iodine (6) Iodine (Kelp, Potassium Iodide) (1) Iodine (Kelp, Seaweed Supplements) (1) Iron (22) iron (2) Iron (Ferric/Ferrous supplements) (1) Iron (Ferrous Sulfate) (3) Iron (oral supplements) (2) Iron (supplemental) (1) Iron (supplements) (1) Iron supplement (2) Iron supplements (1) Iron-containing Ayurvedic formulations (1) Jujube Extract (1) Kaolin-pectin (1) Kava (56) kava (Piper methysticum) (2) L-Arginine (3) L-Theanine (1) Lactobacillus acidophilus (2) Lactobacillus rhamnosus GG (2) Lead-containing Ayurvedic compounds (1) Lemon Balm (5) Levodopa (L-DOPA) (1) Levothyroxine (T4 thyroid replacement) (1) Lions Mane (1) Lithium (Prescription) (1) Loratadine (1) Lutein (1) Maca (1) Magnesium (56) magnesium (2) Magnesium (antacids/supplements) (1) Magnesium (High Dose) (1) Magnesium (Magnesium Glycinate/Citrate) (1) Magnesium (Magnesium Oxide/Citrate) (1) Magnesium (oral supplements) (1) Magnesium Citrate (1) Magnesium Hydroxide (Antacid) (1) Magnesium Hydroxide / Aluminum Hydroxide (Maalox) (1) Magnesium L-Threonate (1) Magnesium supplement (2) Magnesium Taurate (1) Magnesium-containing antacids (1) MAOIs (e.g., Phenelzine, Selegiline) (1) MAOIs (e.g., Phenelzine, Tranylcypromine) (1) Meals high in bran (dietary fiber) (1) melatonin (2) Melatonin (17) Mercury sulfide-containing TCM formulations (1) Metformin (1) Methimazole / Propylthiouracil (antithyroid drugs) (1) Methotrexate (1) Milk Thistle (62) Multivitamins (with multivalent cations) (1) Myo-Inositol (3) NAC (3) NAC (N-Acetylcysteine) (3) NAD Precursors (Niacin/Nicotinamide Riboside) (1) NAD Precursors (Nicotinamide Riboside) (1) Nephrotoxic Antibiotics (Gentamicin/Tobramycin) (1) Niacin (Vitamin B3) (3) Niacinamide (Nicotinamide / Vitamin B3) (1) Niacinamide (Nicotinamide) (1) Nitrous Oxide (Laughing Gas) (1) NMN (Nicotinamide Mononucleotide) (3) NSAIDs (Ibuprofen, Naproxen) (1) NSAIDs (Ibuprofen/Naproxen) (1) Nutritional Supplements / Enteral Feeding Preparations (1) Omega-3 (2) Omega-3 Fatty Acids (Fish Oil) (2) Papain (1) PDE5 Inhibitors (Sildenafil/Tadalafil) (1) Pectin (2) Phenylephrine (OTC energy blends) (1) Phosphatidylserine (2) Phosphorus (1) Potassium (17) Potassium (oral supplements) (1) Potassium Chloride (1) Potassium Iodide (SSKI/KI) (1) potassium supplements (1) Potassium supplements (1) Potassium-containing salt substitutes (1) PQQ (Pyrroloquinoline Quinone) (2) Probiotics (7) Probiotics (Lactobacillus, Bifidobacterium species) (1) Protein Supplements (Whey/Casein) (1) Protein Supplements (Whey/Casein/Plant Protein) (1) Psyllium Husk (2) Psyllium Husk / Dietary Fiber (1) Psyllium Husk / Fiber Supplements (1) Psyllium Husk / Soluble Fiber Supplements (1) Pterostilbene (1) Quercetin (4) Red Clover (3) Red Yeast Rice (2) Reishi (Ganoderma lucidum) (4) Resveratrol (6) Rhodiola (3) Riboflavin (Vitamin B2) (2) royal jelly (1) Saccharomyces boulardii (3) saffron (Crocus sativus) (2) Sage Extract (2) Salicylates (e.g., Willow Bark) (1) SAM-e (2) Schisandra sphenanthera Extract (1) Selenium (8) Serrapeptase (2) Shatavari root extract (1) Siberian Ginseng (1) Silica (2) Slow-Release Nicotinic Acid (Niacin) (1) Sodium (1) Sodium (Low-Sodium Diets) (1) Soy (1) Soy Isoflavones (2) Soybean / Soy Flour (1) Soybean flour / Soy (1) Spermidine (2) Spirulina (3) SSRIs (e.g., Sertraline, Fluoxetine) (1) St Johns Wort (4) St. John's Wort (92) St. John's Wort (Hypericum perforatum) (2) Stimulant ADHD medications (e.g., Amphetamine, Methylphenidate) (2) Sulfite Oxidase Pathway Substrates (High Sulfur Amino Acid Supplements: Methionine, Cysteine, Taurine) (1) Swarna Bhasma (Gold ash) (1) Taurine (3) Taurine (commonly co-supplemented) (1) Thiamine (B1) (2) Thiamine (Vitamin B1) (1) Thyroid supplements (1) Tobacco (Smoking) (1) Tongkat Ali (2) Tramadol (1) Triphala (Terminalia chebula, T. bellerica, Emblica officinalis) (1) Tryptophan (12) TUDCA (2) Turkey Tail (Trametes versicolor) (2) Turmeric (9) Turmeric (Curcuma longa extract) (2) Tyramine-containing foods (cheese, red wine) (1) Tyrosine (2) Unregulated TCM patent medicines (1) Urolithin A (3) Valerian (9) Valproic Acid (Valproate) (1) Vitamin A (2) Vitamin A (Retinol/Beta-Carotene) (1) Vitamin B Complex (B1, B6, B12, Folate) (1) Vitamin B Complex (B1, B6, B9, B12) (1) Vitamin B12 (6) vitamin B12 (1) Vitamin B12 (Cobalamin) (5) Vitamin B12 (Cyanocobalamin) (3) Vitamin B12 (high-dose) (1) Vitamin B12 (Methylcobalamin) (4) Vitamin B12 (oral supplements) (1) Vitamin B2 (Riboflavin) (1) Vitamin B6 (1) Vitamin B6 (Pyridoxal-5-Phosphate) (1) Vitamin B6 (Pyridoxine) (4) Vitamin B6, B12, and Folate (B-Complex) (1) Vitamin C (4) Vitamin C (Ascorbic Acid) (5) Vitamin C (Ascorbic acid) (1) Vitamin C (High Dose ≥1000mg/day) (2) Vitamin C (High-dose) (1) Vitamin C high dose (3) Vitamin D (23) Vitamin D3 (5) Vitamin E (3) Vitamin E (Alpha-Tocopherol) (1) Vitamin E (High-dose) (1) Vitamin E (Tocopherol) (2) Vitamin E high dose (2) Vitamin K (1) Vitamin K (dietary) (2) Vitamin K (oral supplements) (1) Vitamin K2 (Menaquinone) (1) Vitamin K2 (Menaquinone-7, MK-7) (1) Vitex (Chaste Tree Berry) (2) Walnuts (1) Warfarin (1) Warfarin/Antiplatelet Agents (1) White Kidney Bean (2) White Willow (3) Willow Bark (3) Zinc (28) Zinc (High Dose) (1) Zinc (oral supplements) (2) Zinc (Zinc Sulfate/Gluconate) (1) Zinc Carnosine (2) Zinc Picolinate (1) Zinc supplement (2)

5-Fluorouracil (5-FU) (1) 5-HTP (3) Acarbose (1) ACE Inhibitors (class) (1) ACE Inhibitors (e.g., Enalapril) (1) ACE Inhibitors (e.g., Lisinopril) (1) Acenocoumarol (4) Acetaminophen (4) Acetaminophen (Paracetamol) (1) Activated Charcoal (3) Adderall (3) Albuterol (3) Alcohol (2) Allopurinol (4) Alprazolam (11) Amiodarone (3) amiodarone (2) Amitriptyline (3) Amlodipine (15) Amoxicillin (3) Amoxicillin-Clavulanate (2) Amphetamine (2) Amphotericin B (1) Ampicillin (1) Anticoagulants (general) (1) antineoplastic chemotherapy (cytotoxic) (1) Antithrombotic therapy (general) (1) Apixaban (17) Apixaban (Eliquis) (1) Aripiprazole (12) Armour Thyroid (4) Aspirin (8) Atenolol (4) Atomoxetine (2) Atorvastatin (13) atorvastatin (2) Ayurvedic herbs (heavy metal-containing formulations) (1) Ayurvedic herbs (Mahayograj Guggulu) (1) Ayurvedic herbs (Navayasa Churna) (1) Azathioprine (1) Azithromycin (1) Benazepril (3) Bentonite Clay (2) Beta Alanine (2) Bictegravir (2) Birth control pills (1) Bleomycin (1) Bortezomib (Velcade) (1) Bromelain (2) Budesonide (1) Bupropion (3) Buspirone (11) buspirone (1) Butterbur (3) Caffeine (9) Calcitriol (Active Vitamin D) (1) Calcium carbonate (3) Calcium citrate (2) Calcium supplement (3) Candesartan (4) Capecitabine (1) Captopril (3) Carbamazepine (15) carbamazepine (2) Carboplatin (1) Carvedilol (5) Celecoxib (6) Chlorella (1) Chlorophyll (2) Chlorthalidone (2) Chlorzoxazone (2) Cholestyramine (1) Chromium (3) Ciprofloxacin (8) ciprofloxacin (3) Cisplatin (4) Cisplatin (DDP) (1) citalopram (2) Citalopram (3) Citrulline (2) Clarithromycin (10) Clindamycin (2) Clomiphene Citrate (Clomid) (1) Clonazepam (4) Clopidogrel (8) Clozapine (2) clozapine (2) Codeine (10) Colchicine (3) colchicine (1) Collagen Peptides (3) CoQ10 Ubiquinol (1) Creatine (3) Cyclophosphamide (3) cyclosporine (3) Cyclosporine (16) CYP450-metabolized drugs (general) (1) Cytomel (2) cytotoxic chemotherapy (general) (1) Dabigatran (14) Desipramine (2) Dexamethasone (2) Dextromethorphan (2) Diatomaceous Earth (2) Diazepam (1) Diclofenac (4) Digoxin (3) digoxin (10) Diltiazem (12) Direct-Acting Oral Anticoagulants (DOACs) — excluding Dabigatran (1) Docetaxel (1) Dolutegravir (3) Donepezil (4) Doxorubicin (3) Doxycycline (6) doxycycline (10) duloxetine (3) Duloxetine (6) Edoxaban (11) Efavirenz (2) Enalapril (8) Enflurane (2) Epadel (Icosapentaenoic acid prescription EPA) (1) Erythromycin (10) Escitalopram (7) escitalopram (2) Esomeprazole (2) Estradiol (5) Eszopiclone (3) Ethinyl estradiol (5) etidronate (2) everolimus (1) Febuxostat (3) Felodipine (11) Fentanyl (10) fentanyl (1) Fluconazole (16) Fluoxetine (12) fluoxetine (1) Fluticasone (2) Fluvastatin (4) Fluvoxamine (6) fluvoxamine (2) Folate high dose (2) Furosemide (11) GABA (2) gabapentin (3) Gabapentin (2) Galantamine (2) Gelatin (1) Gemcitabine (1) Glibenclamide (4) Glimepiride (1) Glipizide (11) Glucophage (1) Glyburide (4) Gonadotropins (FSH/LH injectables, e.g., Gonal-F, Menopur) (1) Haloperidol (10) Halothane (2) Heparin (2) Hormone Replacement Therapy (Estradiol) (2) Hormone Replacement Therapy (Progesterone/Progestins) (1) Hydralazine (2) Hydrochlorothiazide (6) Hydrocodone (5) Hydrocortisone (2) Hydroxyzine (2) ibandronate (2) Ibuprofen (9) Imatinib (11) Imatinib (Gleevec) (2) Immunosuppressants (e.g., Cyclosporine, Tacrolimus) (1) indinavir (1) Indinavir (9) Inositol (2) Insulin (10) Insulin (Basal/Bolus Therapy) (1) Insulin Glargine (1) Invokana (2) Iodine (2) Irbesartan (7) Iron (1) Iron supplement (4) Isoflurane (2) Isoniazid (2) isoniazid (3) Isotretinoin (2) Itraconazole (14) Januvia (2) Jardiance (3) Ketoconazole (10) L-Methylfolate (2) L-Theanine (2) L-Tyrosine (3) Lansoprazole (2) Letrozole (12) Letrozole (Femara) (1) Levothyroxine (16) levothyroxine (7) Liothyronine (4) Liraglutide (2) Lisinopril (11) lisinopril (2) Lithium (2) Lithium Orotate (3) Lorazepam (4) Losartan (8) Lovastatin (11) Loxoprofen (1) Magnesium L-Threonate (2) Melatonin (2) Melatonin Extended Release (3) Memantine (2) Meperidine (Pethidine) (1) Metformin (28) Methadone (10) Methimazole (2) Methotrexate (6) methotrexate (4) Methylprednisolone (3) Metoclopramide (2) Metoprolol (6) Metronidazole (2) Midazolam (10) Minocycline (1) Mirtazapine (2) mirtazapine (3) Modified Citrus Pectin (3) Molybdenum (2) Monoamine Oxidase Inhibitors (MAOIs) (1) Montelukast (2) Mycophenolate Mofetil (2) Mycophenolate mofetil (1) Naproxen (10) Niacin high dose (3) Nifedipine (12) Nitroglycerin (1) Nitrosamines (2) NMN (1) Norethindrone (4) Nortriptyline (2) NP Thyroid (3) NSAIDs (general) (1) Olanzapine (5) olanzapine (1) Omeprazole (3) Ondansetron (2) opioids (general) (1) oral contraceptives (1) Oral Contraceptives (2) Oral contraceptives (8) Oral Contraceptives (OCP) — used for cycle regulation pre-IVF (1) Oxaliplatin (1) Oxycodone (12) Ozempic (5) Paclitaxel (1) Pancreatin (1) Pantoprazole (2) Paroxetine (6) paroxetine (2) Pea Protein (2) Phenobarbital (1) Phenytoin (4) phenytoin (6) Pravastatin (1) Prednisolone (4) Prednisone (7) Pregabalin (2) Progesterone (Prometrium, Endometrin, Crinone) (1) Propranolol (4) Propylthiouracil (PTU) (1) Quercetin (3) Quetiapine (13) quetiapine (1) Quinapril (1) Rabeprazole (2) Ramelteon (3) Ramipril (3) Ranolazine (2) Rifaximin (1) Risedronate (3) Risperidone (5) Ritalin (3) Ritonavir (10) Rivaroxaban (15) Rivastigmine (2) Rosuvastatin (6) rosuvastatin (1) SAM-e (3) Saquinavir (10) Sedative/Anxiolytic medications (e.g., Benzodiazepines) (1) Selective Serotonin Reuptake Inhibitors (SSRIs) (1) Selenium (3) Semaglutide (6) Semaglutide (Ozempic) (13) Semaglutide (Wegovy) (8) Semaglutide, Liraglutide (Ozempic, Wegovy) (9) Serotonergic Antidepressants (SSRIs, SNRIs) (1) Sertraline (6) sertraline (1) Shatavari (Asparagus racemosus) (1) Sildenafil (11) Simvastatin (12) simvastatin (2) Sirolimus (1) sirolimus (3) Sitagliptin (1) Spironolactone (2) Statin Medications (e.g., Atorvastatin, Rosuvastatin) (1) Statins (e.g., atorvastatin, rosuvastatin, simvastatin) (1) Statins (e.g., atorvastatin, simvastatin, rosuvastatin) (1) Stimulant medications (e.g., Amphetamines) (1) Stinging Nettle (2) Strattera (2) Sulfonylureas (e.g., Glipizide, Glyburide) (1) Synthroid (3) Tacrine (2) Tacrolimus (16) tacrolimus (5) Tadalafil (10) Tamoxifen (17) TCM supplements (general heavy metal-contaminated products) (1) TCM supplements (Realgar / Xiong Huang) (1) TCM supplements (Zhu Sha / Cinnabar) (1) Temazepam (2) Tenofovir (3) Testosterone (3) Tetracycline (3) Theophylline (5) Thioridazine (2) Thyroid Hormone (Levothyroxine) (1) Timolol (2) Tirzepatide (Mounjaro) (5) Tizanidine (2) Tolbutamide (4) Torsemide (6) Tramadol (8) Trazodone (1) trazodone (2) Triazolam (10) Tricyclic Antidepressants (Amitriptyline, Nortriptyline, Doxepin, Imipramine, Desipramine, Amoxapine) (1) Triphala (1) Trulicity (3) Valproate (8) Valsartan (7) Vancomycin (Oral) (1) Vardenafil (10) venlafaxine (5) Venlafaxine (5) Verapamil (12) vilazodone (2) Vitamin A high dose (2) Vitamin B12 (1) Vitamin B6 high dose (2) Vitamin D3 (3) Vitamin K2 (2) Voriconazole (3) Vyvanse (2) warfarin (11) Warfarin (49) warfarin sodium (8) Wegovy (5) Whey Protein (4) Zeolite (3) Zinc Carnosine (1) Zinc supplement (3) Zolpidem (4) zolpidem (2)