Is ACE Inhibitors (Lisinopril/Enalapril) Safe with Creatine?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Use with caution. Ensure adequate hydration during exercise. Monitor serum creatinine and BUN levels every 3 months. Report any swelling, decreased urination, or fatigue to your physician.
Why this interaction occurs
ACE inhibitors reduce efferent arteriolar tone, lowering intraglomerular pressure to protect kidneys long-term but reducing acute filtration reserve. High-dose creatine (>5g/day) increases metabolic load on the kidneys. In patients with pre-existing renal impairment or hypertension managed with ACE inhibitors, this combination may accelerate decline in eGFR.
Evidence
Evidence level: moderate.
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 1,051 reports mentioning Creatine. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Creatine + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All ACE Inhibitors (Lisinopril/Enalapril) interactions → · All Creatine interactions →
Already checked this one — check your whole list
Educational only — not medical advice.
Always confirm with your doctor or pharmacist.