Is Amiodarone (high iodine content cardiac drug) Safe with Iodine?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Avoid high-dose iodine unless directed. Monitor thyroid labs.
Why this interaction occurs
Amiodarone contains approximately 37% iodine by weight and releases large amounts of free iodine during metabolism. Adding exogenous iodine supplements creates massive iodine excess, triggering either amiodarone-induced thyrotoxicosis (AIT type I) via the Jod-Basedow effect or amiodarone-induced hypothyroidism (AIH) via the Wolff-Chaikoff effect. Both conditions carry serious cardiovascular consequences in arrhythmia patients.
Evidence
Evidence level: strong.
Data source
Razvi et al., JACC 2018; Joglar et al., 2023 ACC/AHA AF Guideline; Ross et al., ATA 2016
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 7,125 reports mentioning Iodine. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Iodine + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All Amiodarone (high iodine content cardiac drug) interactions → · All Iodine interactions →
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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.