Is Benzodiazepines (e.g., Lorazepam, Clonazepam) Safe with L-Theanine?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Avoid combining L-Theanine with benzodiazepines without medical guidance. Do not drive or operate heavy machinery if using this combination. Monitor for excessive sedation, dizziness, or impaired coordination.
Why this interaction occurs
L-Theanine modulates GABA receptor activity and exerts anxiolytic and mild sedative properties. When combined with benzodiazepines, which potentiate GABAergic inhibition, there is a risk of additive CNS depressant effects including excessive sedation and psychomotor impairment.
Evidence
Evidence level: limited.
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 36,135 reports mentioning L-Theanine. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the L-Theanine + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All Benzodiazepines (e.g., Lorazepam, Clonazepam) interactions → · All L-Theanine interactions →
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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.