Is Bifidobacterium longum Safe with Amoxicillin-Clavulanate?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Separate doses by a minimum of 2 hours. Take Bifidobacterium after meals when antibiotic levels are being absorbed, and continue for 4 weeks post-antibiotic to counter antibiotic-associated diarrhea risk.
Why this interaction occurs
Amoxicillin-clavulanate significantly disrupts the gut microbiome, including Bifidobacterium species. Co-administration reduces live bacterial counts and probiotic efficacy. Clinical trials demonstrate that strategic dosing separation reduces antibiotic-associated diarrhea incidence compared to concurrent use.
Evidence
Evidence level: strong.
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 115,691 reports mentioning Amoxicillin-Clavulanate. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Amoxicillin-Clavulanate + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All Bifidobacterium longum interactions → · All Amoxicillin-Clavulanate interactions →
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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.