Is Biotin Safe with Carbamazepine?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Be alert to signs of biotin deficiency such as hair thinning, skin rash, or unusual fatigue during long-term therapy. Consult your physician about biotin monitoring or supplementation if symptoms arise.
Why this interaction occurs
Carbamazepine has been shown to accelerate biotin catabolism and reduce plasma biotin levels, likely through induction of enzymes that degrade biotin. Chronic deficiency can impair carboxylase-dependent metabolic pathways and has been associated with neurological deterioration.
Evidence
Evidence level: moderate.
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 37,681 reports mentioning Carbamazepine. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Carbamazepine + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All Biotin interactions → · All Carbamazepine interactions →
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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.