Is Cannabidiol (CBD) Safe with tacrolimus?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Consult your healthcare provider before using CBD products. Therapeutic drug monitoring and possible tacrolimus dose reduction should be considered when used together.
Why this interaction occurs
Co-administration of cannabidiol with tacrolimus may alter tacrolimus concentrations, requiring therapeutic drug monitoring and potential dose reduction of tacrolimus.
Evidence
Evidence level: strong.
Data source
FDA Drug Label
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 130,929 reports mentioning tacrolimus. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the tacrolimus + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All Cannabidiol (CBD) interactions → · All tacrolimus interactions →
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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.