Is Chromium Safe with Januvia?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Inform your healthcare provider if you are taking chromium supplements. Self-monitor blood glucose more frequently and report episodes of low blood sugar.
Why this interaction occurs
Chromium improves insulin receptor sensitivity and glucose metabolism. When combined with Januvia (sitagliptin), which enhances incretin-mediated insulin secretion, additive glucose lowering may occur and could increase hypoglycemia risk particularly in renally impaired patients.
Evidence
Evidence level: limited.
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 62,404 reports mentioning Januvia. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Januvia + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All Chromium interactions → · All Januvia interactions →
Already checked this one — check your whole list
Educational only — not medical advice.
Always confirm with your doctor or pharmacist.