Is Copper Bisglycinate Safe with Magnesium L-Threonate?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Separate doses by 1-2 hours when possible. Glycinate chelation of copper reduces but does not eliminate competitive absorption concerns. Evening magnesium and morning copper dosing is an optimal strategy.
Why this interaction occurs
Magnesium and copper can compete at intestinal absorption sites, though the bisglycinate chelate form of copper has enhanced transporter-independent uptake reducing competitive interaction risk significantly. High doses of magnesium (above 400mg elemental) may still modestly impair copper absorption over time, particularly with chronic concurrent use.
Evidence
Evidence level: moderate.
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 1,898,591 reports mentioning Magnesium L-Threonate. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Magnesium L-Threonate + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All Copper Bisglycinate interactions → · All Magnesium L-Threonate interactions →
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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.