Is Cordyceps (Cordyceps sinensis/militaris) Safe with Metformin?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Monitor blood glucose more frequently if combining Cordyceps with metformin. Discuss dose adjustments with your provider and watch for symptoms of low blood sugar (dizziness, sweating, confusion).
Why this interaction occurs
Cordyceps has demonstrated hypoglycemic effects in both animal studies and limited human trials, potentially through enhanced insulin sensitivity and glucose metabolism. Combined with metformin, this may produce additive blood glucose lowering and increase hypoglycemia risk.
Evidence
Evidence level: limited.
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 432,898 reports mentioning Metformin. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Metformin + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All Cordyceps (Cordyceps sinensis/militaris) interactions → · All Metformin interactions →
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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.