Check my stack

Is Echinacea Safe with Acetaminophen?

ℹ️ MODERATE SEVERITY
CHECK MY STACK
Acetaminophen Echinacea
Check these in my full stack →

Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature

WHAT YOU NEED TO KNOW

Avoid combining Echinacea with Acetaminophen — Echinacea blocks the liver enzyme (CYP1A2) that processes Acetaminophen, potentially raising Acetaminophen levels to toxic range. Consult your doctor or pharmacist.

Why this interaction occurs

Echinacea inhibits CYP1A2. Result: increased drug levels.

Evidence

Evidence level: moderate.

Reported safety data

The FDA’s adverse event reporting system (FAERS) has received 487,910 reports mentioning Acetaminophen. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Acetaminophen + supplement combination on this page.

FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.

Frequently asked questions

Can I take Echinacea with Acetaminophen?
Avoid combining Echinacea with Acetaminophen — Echinacea blocks the liver enzyme (CYP1A2) that processes Acetaminophen, potentially raising Acetaminophen levels to toxic range. Consult your doctor or pharmacist.

Related interactions

St. John's Wort and Acetaminophen Garlic Extract and Acetaminophen Kava and Acetaminophen Echinacea and Cyclosporine Echinacea and 5-Fluorouracil (5-FU) Echinacea and Cisplatin (DDP) Echinacea and Prednisone Echinacea and Tacrolimus

All Echinacea interactions →  ·  All Acetaminophen interactions →

Already checked this one — check your whole list

Check My Full Stack → Generate Visit Packet →
Powered by Elthio Health · elthio.health
Educational only — not medical advice.
Always confirm with your doctor or pharmacist.