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Is Echinacea Safe with Ramelteon?

ℹ️ MODERATE SEVERITY
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Ramelteon Echinacea
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Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature

WHAT YOU NEED TO KNOW

Avoid combining Echinacea with Ramelteon — Echinacea blocks the liver enzyme (CYP1A2) that processes Ramelteon, potentially raising Ramelteon levels to toxic range. Consult your doctor or pharmacist.

Why this interaction occurs

Echinacea inhibits CYP1A2. Result: increased drug levels.

Evidence

Evidence level: moderate.

Reported safety data

The FDA’s adverse event reporting system (FAERS) has received 1,482 reports mentioning Ramelteon. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Ramelteon + supplement combination on this page.

FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.

Frequently asked questions

Can I take Echinacea with Ramelteon?
Avoid combining Echinacea with Ramelteon — Echinacea blocks the liver enzyme (CYP1A2) that processes Ramelteon, potentially raising Ramelteon levels to toxic range. Consult your doctor or pharmacist.

Related interactions

Melatonin and Ramelteon St. John's Wort and Ramelteon Echinacea and Cyclosporine Echinacea and 5-Fluorouracil (5-FU) Echinacea and Cisplatin (DDP) Echinacea and Prednisone Echinacea and Tacrolimus Echinacea and Azathioprine

All Echinacea interactions →  ·  All Ramelteon interactions →

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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.