Is Garlic Extract Safe with Letrozole?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Avoid combining Garlic Extract with Letrozole — Garlic Extract blocks the liver enzyme (CYP3A4) that processes Letrozole, potentially raising Letrozole levels to toxic range. Consult your doctor or pharmacist.
Why this interaction occurs
Allicin compounds inhibit CYP3A4 activity. Result: increased drug levels. May increase levels of HIV medications and statins
Evidence
Evidence level: moderate.
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 49,117 reports mentioning Letrozole. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Letrozole + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All Garlic Extract interactions → · All Letrozole interactions →
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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.