Is Glutathione Safe with Carboplatin?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Avoid glutathione supplementation during carboplatin chemotherapy. Elevated glutathione is a primary resistance mechanism to platinum-based agents. Consult your oncologist before taking any antioxidant supplements.
Why this interaction occurs
Similar to cisplatin, carboplatin's cytotoxicity depends on platinum-DNA adduct formation. Glutathione binds to platinum compounds, reducing the amount of active drug available to interact with tumor cell DNA. Elevated tissue GSH is strongly associated with carboplatin resistance in ovarian and lung cancers.
Evidence
Evidence level: strong.
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 131,104 reports mentioning Carboplatin. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Carboplatin + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All Glutathione interactions → · All Carboplatin interactions →
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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.