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Is Goldenseal Safe with Codeine?

⚠️ HIGH SEVERITY
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Codeine Goldenseal
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Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature

WHAT YOU NEED TO KNOW

Avoid combining Goldenseal with Codeine — Goldenseal blocks the liver enzyme (CYP3A4) that processes Codeine, potentially raising Codeine levels to toxic range. Consult your doctor or pharmacist.

Why this interaction occurs

Berberine and hydrastine inhibit CYP3A4. Result: increased drug levels. May increase drug toxicity

Evidence

Evidence level: moderate.

Reported safety data

The FDA’s adverse event reporting system (FAERS) has received 100,795 reports mentioning Codeine. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Codeine + supplement combination on this page.

FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.

Frequently asked questions

Can I take Goldenseal with Codeine?
Avoid unless your doctor or pharmacist directs otherwise. Avoid combining Goldenseal with Codeine — Goldenseal blocks the liver enzyme (CYP3A4) that processes Codeine, potentially raising Codeine levels to toxic range. Consult your doctor or pharmacist.

Related interactions

Kava and Codeine St. John's Wort and Codeine Grapefruit and Codeine Berberine and Codeine Milk Thistle and Codeine Curcumin and Codeine Echinacea and Codeine Ginkgo Biloba and Codeine

All Goldenseal interactions →  ·  All Codeine interactions →

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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.