Is Goldenseal Safe with Simvastatin?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Avoid combining Goldenseal with Simvastatin — Goldenseal blocks the liver enzyme (CYP3A4) that processes Simvastatin, potentially raising Simvastatin levels to toxic range. Consult your doctor or pharmacist.
Why this interaction occurs
Berberine and hydrastine inhibit CYP3A4. Result: increased drug levels. May increase drug toxicity
Evidence
Evidence level: moderate.
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 213,170 reports mentioning Simvastatin. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Simvastatin + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All Goldenseal interactions → · All Simvastatin interactions →
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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.