Is Grapefruit / Grapefruit Juice Safe with Atorvastatin?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Avoid large quantities of grapefruit or grapefruit juice. Occasional small amounts may be tolerable at lower atorvastatin doses, but avoidance is the safest approach. Consult your pharmacist for personalized guidance.
Why this interaction occurs
Grapefruit-derived furanocoumarins inhibit this enzyme, increasing atorvastatin plasma levels and the associated risk of myopathy.
Evidence
Evidence level: strong.
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 343,939 reports mentioning Atorvastatin. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Atorvastatin + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All Grapefruit / Grapefruit Juice interactions → · All Atorvastatin interactions →
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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.