Is Grapefruit Juice Safe with Felodipine?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Avoid all grapefruit and grapefruit juice while taking this medication. Even a single glass can significantly increase drug levels in your blood.
Why this interaction occurs
Grapefruit juice contains furanocoumarins that irreversibly inhibit intestinal CYP3A4 enzymes, drastically reducing first-pass metabolism of felodipine and increasing plasma concentrations by up to 3-fold, raising risk of severe hypotension, reflex tachycardia, and toxicity.
Evidence
Evidence level: strong.
Data source
PubMed: PMID 40646684, PMID 29703387
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 11,893 reports mentioning Felodipine. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Felodipine + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All Grapefruit Juice interactions → · All Felodipine interactions →
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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.