Is Grapefruit Juice Safe with warfarin sodium?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Discuss grapefruit juice consumption with your doctor. Avoid drastic changes in your intake of grapefruit juice and monitor INR if consumption changes.
Why this interaction occurs
Grapefruit juice can interact with warfarin sodium through CYP450 interactions, potentially increasing warfarin exposure and its anticoagulant effect.
Evidence
Evidence level: strong.
Data source
FDA Drug Label
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 3,390,437 reports mentioning warfarin sodium. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the warfarin sodium + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All Grapefruit Juice interactions → · All warfarin sodium interactions →
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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.