Is Iodine Safe with Methimazole?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Avoid iodine supplements during methimazole therapy unless specifically directed by your endocrinologist. Report any palpitations, sweating, or weight changes promptly.
Why this interaction occurs
High iodine intake increases substrate availability for thyroid hormone synthesis, potentially overwhelming methimazole's inhibitory mechanism and worsening hyperthyroidism control.
Evidence
Evidence level: strong.
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 8,031 reports mentioning Methimazole. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Methimazole + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All Iodine interactions → · All Methimazole interactions →
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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.