Is Iron Safe with Semaglutide, Liraglutide (Ozempic, Wegovy)?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Monitor serum ferritin, hemoglobin, and transferrin saturation every 6–12 months, especially in premenopausal women. If deficient, supplement with ferrous bisglycinate (25–50 mg elemental iron) for better tolerability given existing GI side effects. Take iron with vitamin C to enhance absorption and separate from calcium or antacids by 2 hours.
Why this interaction occurs
GLP-1 agonists reduce gastric acid output, which is essential for converting dietary ferric iron (Fe3+) to absorbable ferrous iron (Fe2+). Delayed gastric emptying further impairs iron transit to the duodenum, the primary site of iron absorption. Appetite suppression also reduces intake of iron-rich foods. Collectively, these mechanisms place patients at significant risk for iron deficiency anemia, particularly those with pre-existing low iron stores.
Evidence
Evidence level: moderate.
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 146,406 reports mentioning Semaglutide, Liraglutide (Ozempic, Wegovy). This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Semaglutide, Liraglutide (Ozempic, Wegovy) + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All Iron interactions → · All Semaglutide, Liraglutide (Ozempic, Wegovy) interactions →
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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.