Is Iron (oral supplements) Safe with Zeolite?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Separate iron supplement intake from zeolite by at least 4 hours. Take iron first, then zeolite later in the day.
Why this interaction occurs
Clinoptilolite zeolite has a high cation exchange capacity and can adsorb positively charged metal ions including iron (Fe²⁺/Fe³⁺) in the GI tract, significantly reducing bioavailability of oral iron supplements.
Evidence
Evidence level: moderate.
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 31 reports mentioning Zeolite. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Zeolite + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All Iron (oral supplements) interactions → · All Zeolite interactions →
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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.