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Is Iron (supplemental) Safe with Iron?

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Iron Iron (supplemental)
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Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature

WHAT YOU NEED TO KNOW

Separate iron supplements and ACE inhibitors (e.g., captopril, lisinopril) by at least 2 hours. Take iron on an empty stomach unless GI upset occurs. Inform your prescriber of iron supplementation.

Why this interaction occurs

Iron chelates with ACE inhibitors, forming insoluble complexes that reduce bioavailability of both agents. Additionally, concurrent use may worsen GI side effects. Captopril-iron interaction has been documented to reduce captopril absorption by up to 37%.

Evidence

Evidence level: strong.

Reported safety data

The FDA’s adverse event reporting system (FAERS) has received 86,422 reports mentioning Iron. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Iron + supplement combination on this page.

FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.

Frequently asked questions

Can I take Iron (supplemental) with Iron?
Avoid unless your doctor or pharmacist directs otherwise. Separate iron supplements and ACE inhibitors (e.g., captopril, lisinopril) by at least 2 hours. Take iron on an empty stomach unless GI upset occurs. Inform your prescriber of iron supplementation.
How long should I wait between Iron and Iron (supplemental)?
Separate iron supplements and ACE inhibitors (e.g., captopril, lisinopril) by at least 2 hours. Take iron on an empty stomach unless GI upset occurs. Inform your prescriber of iron supplementation.
Does Iron (supplemental) affect how well Iron works?
Iron chelates with ACE inhibitors, forming insoluble complexes that reduce bioavailability of both agents. Additionally, concurrent use may worsen GI side effects. Captopril-iron interaction has been documented to reduce captopril absorption by up to 37%.

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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.