Is Jujube Extract Safe with Trazodone?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Use caution when combining Jujube Extract with Trazodone. Avoid nighttime activities requiring alertness. Discuss with your prescriber if sleep becomes excessively deep or difficult to rouse from.
Why this interaction occurs
Jujube seed extract (Ziziphus jujuba) contains saponins (jujubosides) and flavonoids that modulate GABA-A receptors and serotonergic activity, promoting sleep. Trazodone is a serotonin antagonist and reuptake inhibitor (SARI) with sedative antihistaminergic properties. Overlapping serotonergic and GABAergic mechanisms may produce additive sedation beyond the intended therapeutic level.
Evidence
Evidence level: limited.
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 122,875 reports mentioning Trazodone. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Trazodone + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
All Jujube Extract interactions → · All Trazodone interactions →
Already checked this one — check your whole list
Educational only — not medical advice.
Always confirm with your doctor or pharmacist.