Is L-Theanine Safe with Vitamin B6 high dose?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Use with caution if operating heavy machinery or driving. Monitor for excessive sedation or dizziness when combining high-dose Vitamin B6 with L-Theanine supplements, particularly in elderly patients.
Why this interaction occurs
High-dose Vitamin B6 influences GABAergic neurotransmission. L-Theanine promotes GABA synthesis and alpha-wave activity. Combined use may produce additive CNS calming effects, though clinical significance remains modest.
Evidence
Evidence level: limited.
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 2,940,765 reports mentioning Vitamin B6 high dose. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Vitamin B6 high dose + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All L-Theanine interactions → · All Vitamin B6 high dose interactions →
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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.