Is Magnesium Safe with Calcium citrate?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Separating doses by 1-2 hours is preferable but less critical than with calcium carbonate. Monitor for signs of magnesium deficiency such as muscle cramps or fatigue if taking both long-term.
Why this interaction occurs
Calcium citrate competes with magnesium for absorption similarly to other calcium salts, but its superior solubility and absorption profile at lower gastrointestinal pH results in less interference compared to calcium carbonate. The clinical impact is generally modest at typical supplement doses.
Evidence
Evidence level: moderate.
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 1,123,384 reports mentioning Calcium citrate. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Calcium citrate + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All Magnesium interactions → · All Calcium citrate interactions →
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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.