Is Magnesium Safe with Hydrocodone?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
High-dose magnesium supplements (above 350 mg/day) should be used cautiously with hydrocodone. Standard dietary doses are generally safe. Consult your pharmacist if you are unsure about your magnesium dose.
Why this interaction occurs
Magnesium acts as a natural NMDA receptor antagonist and has mild CNS-modulating properties. At high supplemental doses, it may contribute to additive CNS depression when combined with hydrocodone. Evidence for clinically significant interaction is limited, but caution is warranted in patients with renal impairment or those on high-dose magnesium therapy.
Evidence
Evidence level: limited.
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 219,290 reports mentioning Hydrocodone. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Hydrocodone + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All Magnesium interactions → · All Hydrocodone interactions →
Already checked this one — check your whole list
Educational only — not medical advice.
Always confirm with your doctor or pharmacist.