Is Magnesium L-Threonate Safe with Melatonin Extended Release?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Take together only under medical supervision. Start with lowest doses of each and avoid operating machinery or driving after nighttime use.
Why this interaction occurs
Magnesium modulates NMDA receptors and GABA activity, producing CNS depressant effects. Combined with melatonin's sleep-promoting properties via MT1/MT2 receptor agonism, additive sedation may occur. The L-Threonate form crosses the blood-brain barrier more efficiently than other magnesium forms, potentially amplifying CNS effects.
Evidence
Evidence level: moderate.
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 3,038,082 reports mentioning Melatonin Extended Release. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Melatonin Extended Release + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All Magnesium L-Threonate interactions → · All Melatonin Extended Release interactions →
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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.