Is Magnesium (Magnesium Glycinate/Citrate) Safe with Lansoprazole?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Check baseline serum magnesium before initiating long-term lansoprazole. Recheck every 3–6 months. Supplement with magnesium glycinate or citrate (preferred over oxide due to superior bioavailability). Severe hypomagnesemia (<0.5 mmol/L) may require IV magnesium and consideration of PPI discontinuation.
Why this interaction occurs
The FDA issued a safety communication in 2011 warning that PPIs including lansoprazole can cause hypomagnesemia with use exceeding 1 year. The mechanism involves impaired active magnesium transport via TRPM6/TRPM7 channels in the intestinal brush border. Hypomagnesemia can trigger secondary hypokalemia and hypocalcemia due to impaired PTH secretion and renal potassium wasting, creating a dangerous electrolyte cascade.
Evidence
Evidence level: strong.
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 110,199 reports mentioning Lansoprazole. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Lansoprazole + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All Magnesium (Magnesium Glycinate/Citrate) interactions → · All Lansoprazole interactions →
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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.