Is Magnesium supplement Safe with Iron supplement?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Separate iron and magnesium supplementation by at least 1–2 hours. Taking them with food may reduce the interaction but will also moderately decrease iron absorption.
Why this interaction occurs
Magnesium, as a divalent cation, can compete with iron for DMT-1-mediated intestinal absorption. Clinical studies show high-dose magnesium supplementation can modestly reduce iron bioavailability, particularly in non-food contexts.
Evidence
Evidence level: moderate.
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 136,322 reports mentioning Iron supplement. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Iron supplement + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All Magnesium supplement interactions → · All Iron supplement interactions →
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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.