Is Melatonin Safe with Oxycodone?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Use melatonin cautiously with oxycodone and only at the lowest effective dose. Avoid higher melatonin doses (above 1–3 mg). Do not drive after taking this combination and notify your doctor of all supplements.
Why this interaction occurs
Melatonin has mild CNS depressant and sedative properties. When combined with oxycodone, additive sedation may occur. While the interaction is generally less severe than with valerian or kava, higher melatonin doses or extended-release formulations may meaningfully increase oxycodone-related somnolence.
Evidence
Evidence level: limited.
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 298,224 reports mentioning Oxycodone. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Oxycodone + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All Melatonin interactions → · All Oxycodone interactions →
Already checked this one — check your whole list
Educational only — not medical advice.
Always confirm with your doctor or pharmacist.