Is Myo-Inositol Safe with Thyroid Hormone (Levothyroxine)?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Monitor TSH levels periodically when initiating myo-inositol in patients on levothyroxine. Thyroid hormone dose may need adjustment. Inform your endocrinologist about myo-inositol use.
Why this interaction occurs
Myo-inositol plays a role in TSH receptor signal transduction in thyroid follicular cells. Clinical studies in subclinical hypothyroidism (particularly Hashimoto's thyroiditis) show myo-inositol supplementation can reduce TSH levels. In patients stabilized on levothyroxine, this may shift thyroid function and require dose recalibration.
Evidence
Evidence level: moderate.
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 2,076,948 reports mentioning Thyroid Hormone (Levothyroxine). This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Thyroid Hormone (Levothyroxine) + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All Myo-Inositol interactions → · All Thyroid Hormone (Levothyroxine) interactions →
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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.