Is Niacinamide (Nicotinamide / Vitamin B3) Safe with carbamazepine?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Avoid taking niacinamide (nicotinamide) supplements without consulting your doctor. Close monitoring of carbamazepine plasma levels and possible dosage adjustment may be required.
Why this interaction occurs
Niacinamide (nicotinamide) has been shown or would be expected to increase plasma carbamazepine levels, likely through inhibition of CYP3A4-mediated carbamazepine metabolism, potentially leading to carbamazepine toxicity.
Evidence
Evidence level: strong.
Data source
FDA Drug Label
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 37,681 reports mentioning carbamazepine. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the carbamazepine + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All Niacinamide (Nicotinamide / Vitamin B3) interactions → · All carbamazepine interactions →
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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.