Is NMN (Nicotinamide Mononucleotide) Safe with Sulfonylureas (e.g., Glipizide, Glyburide)?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Use caution combining NMN with sulfonylureas. Increase self-monitoring of blood glucose frequency. Report dizziness, sweating, or confusion to your physician immediately.
Why this interaction occurs
Sulfonylureas stimulate pancreatic beta-cell insulin secretion by closing ATP-sensitive potassium channels. NMN elevates intracellular NAD+ and ATP levels in beta cells, which may independently potentiate insulin secretion through the same KATP channel mechanism. The combination could produce an additive insulinotropic effect, increasing the risk of hypoglycemia, particularly in elderly patients or those skipping meals.
Evidence
Evidence level: limited.
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 94,098 reports mentioning Sulfonylureas (e.g., Glipizide, Glyburide). This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Sulfonylureas (e.g., Glipizide, Glyburide) + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All NMN (Nicotinamide Mononucleotide) interactions → · All Sulfonylureas (e.g., Glipizide, Glyburide) interactions →
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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.