Is Nutritional Supplements / Enteral Feeding Preparations Safe with phenytoin?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Do not take phenytoin at the same time as enteral feeding preparations or nutritional supplements. More frequent phenytoin level monitoring may be necessary.
Why this interaction occurs
Literature reports suggest patients receiving enteral feeding preparations and/or related nutritional supplements have lower than expected phenytoin serum levels, risking loss of seizure control.
Evidence
Evidence level: strong.
Data source
FDA Drug Label
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 25,235 reports mentioning phenytoin. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the phenytoin + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All Nutritional Supplements / Enteral Feeding Preparations interactions → · All phenytoin interactions →
Already checked this one — check your whole list
Educational only — not medical advice.
Always confirm with your doctor or pharmacist.