Is Omega-3 Fatty Acids (Fish Oil) Safe with Pravastatin?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Omega-3 supplements (1–4 g/day of EPA/DHA) can generally be taken safely with pravastatin and may provide complementary triglyceride-lowering benefits. Monitor for mild additive bleeding risk if also taking anticoagulants. Inform your healthcare provider of all supplements.
Why this interaction occurs
Pravastatin is not significantly metabolized by CYP3A4, minimizing pharmacokinetic interactions with omega-3 fatty acids. The combination offers complementary lipid-modifying effects — statins reduce LDL-C while omega-3s reduce triglycerides. No clinically significant adverse pharmacodynamic interactions have been identified. High-dose omega-3 (>3 g/day) may mildly increase bleeding tendency.
Evidence
Evidence level: moderate.
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 85,067 reports mentioning Pravastatin. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Pravastatin + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All Omega-3 Fatty Acids (Fish Oil) interactions → · All Pravastatin interactions →
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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.