Is Potassium-containing salt substitutes Safe with lisinopril?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Do not use salt substitutes containing potassium without first consulting your physician.
Why this interaction occurs
Lisinopril reduces aldosterone production, which decreases potassium excretion. Adding potassium from salt substitutes can lead to hyperkalemia (elevated serum potassium), which can cause serious cardiac arrhythmias.
Evidence
Evidence level: strong.
Data source
FDA Drug Label
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 323,131 reports mentioning lisinopril. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the lisinopril + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All Potassium-containing salt substitutes interactions → · All lisinopril interactions →
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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.