Is Pterostilbene Safe with Methotrexate?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Avoid pterostilbene supplements during methotrexate therapy. Ensure your oncologist or rheumatologist is aware of all supplements. Report any signs of liver toxicity (jaundice, right upper quadrant pain, fatigue) promptly.
Why this interaction occurs
Methotrexate carries a known hepatotoxicity risk. Pterostilbene, a methylated resveratrol analog with enhanced bioavailability, undergoes hepatic metabolism and may compound liver enzyme elevations when co-administered with methotrexate. Additionally, pterostilbene may inhibit OAT transporters involved in methotrexate renal elimination, risking drug accumulation.
Evidence
Evidence level: limited.
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 499,559 reports mentioning Methotrexate. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Methotrexate + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All Pterostilbene interactions → · All Methotrexate interactions →
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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.