Is Shatavari root extract Safe with Shatavari (Asparagus racemosus)?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Avoid combining Shatavari with lithium carbonate. If used concurrently with diuretics, monitor serum electrolytes and renal function. Patients on lithium should have lithium serum levels checked within 1-2 weeks of starting Shatavari.
Why this interaction occurs
Shatavari has documented diuretic properties. Diuretics reduce renal lithium clearance, elevating serum lithium concentrations into the toxic range (>1.5 mEq/L). Lithium toxicity manifests as tremor, confusion, renal failure, and cardiac arrhythmias. Additionally, Shatavari-induced natriuresis may alter lithium reabsorption in the proximal tubule.
Evidence
Evidence level: limited.
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 1,596 reports mentioning Shatavari (Asparagus racemosus). This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Shatavari (Asparagus racemosus) + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.