Is Turkey Tail (Trametes versicolor) Safe with Mycophenolate Mofetil?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Avoid Turkey Tail supplements if you are taking mycophenolate for organ transplant or autoimmune conditions. Discuss with your specialist before use.
Why this interaction occurs
Turkey Tail contains Polysaccharide-K (PSK) and PSP, well-documented immunomodulators that upregulate immune cell activity including T-cells and NK cells. This directly opposes mycophenolate's mechanism of inhibiting lymphocyte proliferation, risking transplant rejection or autoimmune flares.
Evidence
Evidence level: moderate.
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 155,005 reports mentioning Mycophenolate Mofetil. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Mycophenolate Mofetil + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All Turkey Tail (Trametes versicolor) interactions → · All Mycophenolate Mofetil interactions →
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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.