Is Vitamin D Safe with Paroxetine?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Monitor serum 25-OH vitamin D levels. Supplement with 1000–2000 IU of vitamin D3 daily if levels are insufficient (<30 ng/mL). Higher doses may be needed under medical supervision.
Why this interaction occurs
Low vitamin D levels are common in depressed patients and may reduce SSRI efficacy. SSRIs, particularly paroxetine, may alter vitamin D metabolism via CYP enzyme interactions. Vitamin D receptors are present in brain regions involved in mood regulation, and adequate levels may support serotonergic function.
Evidence
Evidence level: moderate.
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 53,308 reports mentioning Paroxetine. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Paroxetine + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All Vitamin D interactions → · All Paroxetine interactions →
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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.