Is Zinc (High Dose) Safe with Folate high dose?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Separate administration of high-dose zinc supplements and folate by at least 2 hours. Avoid sustained high-dose zinc (>40mg/day) during folate therapy. Monitor folate levels if both are required long-term.
Why this interaction occurs
High-dose zinc competitively inhibits intestinal folate absorption by interfering with reduced folate carrier-mediated transport. This can significantly reduce bioavailability of supplemental folate, potentially negating therapeutic intent particularly critical in pregnancy or methotrexate rescue therapy.
Evidence
Evidence level: moderate.
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 2,515,845 reports mentioning Folate high dose. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Folate high dose + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All Zinc (High Dose) interactions → · All Folate high dose interactions →
Already checked this one — check your whole list
Educational only — not medical advice.
Always confirm with your doctor or pharmacist.