Is Amoxicillin Safe with Bromelain?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Inform your physician if taking bromelain alongside amoxicillin or other antibiotics. This combination is not necessarily harmful but may alter antibiotic dosing requirements. Do not self-adjust doses.
Why this interaction occurs
Clinical studies have shown that bromelain enhances the gastrointestinal absorption and tissue bioavailability of amoxicillin. This may increase plasma concentrations of the antibiotic beyond intended therapeutic levels, potentially increasing both efficacy and adverse effect risk.
Evidence
Evidence level: strong.
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 354 reports mentioning Bromelain. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Bromelain + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All Amoxicillin interactions → · All Bromelain interactions →
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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.