Is Warfarin/Antiplatelet Agents Safe with Bromelain?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Seek immediate care if you notice unexplained bruising, prolonged bleeding, blood in urine, or black stools.
Why this interaction occurs
Bromelain possesses fibrinolytic and antiplatelet aggregation properties. When combined with anticoagulant or antiplatelet medications, these additive effects substantially increase the risk of clinically significant hemorrhage. INR monitoring is essential if concurrent use is unavoidable.
Evidence
Evidence level: strong.
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 354 reports mentioning Bromelain. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Bromelain + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All Warfarin/Antiplatelet Agents interactions → · All Bromelain interactions →
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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.