Is Ashwagandha Safe with Immunosuppressants (e.g., Cyclosporine, Tacrolimus)?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Do not use ashwagandha if you are on immunosuppressive therapy without explicit approval from your transplant or specialist physician. Report any signs of organ rejection or immune activation immediately.
Why this interaction occurs
Ashwagandha is a known immunostimulant that activates T-cell and NK-cell activity. This immune-boosting effect can directly antagonize immunosuppressant medications, increasing the risk of organ rejection or autoimmune flares.
Evidence
Evidence level: moderate.
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 297,234 reports mentioning Immunosuppressants (e.g., Cyclosporine, Tacrolimus). This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Immunosuppressants (e.g., Cyclosporine, Tacrolimus) + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All Ashwagandha interactions → · All Immunosuppressants (e.g., Cyclosporine, Tacrolimus) interactions →
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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.