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Is Ashwagandha Safe with Sedative/Anxiolytic medications (e.g., Benzodiazepines)?

ℹ️ MODERATE SEVERITY
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Sedative/Anxiolytic medications (e.g., Benzodiazepines) Ashwagandha
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Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature

WHAT YOU NEED TO KNOW

Use caution when combining ashwagandha with sedative medications. Avoid driving or operating machinery. Discuss dosage adjustments with your healthcare provider.

Why this interaction occurs

Ashwagandha has documented GABAergic and adaptogenic CNS effects. Concurrent use with benzodiazepines or other sedatives may potentiate CNS depression, increasing sedation and psychomotor impairment.

Evidence

Evidence level: moderate.

Frequently asked questions

Can I take Ashwagandha with Sedative/Anxiolytic medications (e.g., Benzodiazepines)?
Use caution when combining ashwagandha with sedative medications. Avoid driving or operating machinery. Discuss dosage adjustments with your healthcare provider.

Related interactions

Ashwagandha and Immunosuppressants (e.g., Cyclosporine, Tacrolimus) Ashwagandha and Levothyroxine Ashwagandha and Methimazole Ashwagandha and Sitagliptin Ashwagandha and digoxin

All Ashwagandha interactions →  ·  All Sedative/Anxiolytic medications (e.g., Benzodiazepines) interactions →

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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.