Is Boron Safe with Estradiol?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Discuss boron supplement use with your prescriber if you are on estradiol HRT. Hormone levels should be monitored. Avoid high-dose boron (above 6 mg/day) to prevent estrogen excess.
Why this interaction occurs
Clinical studies show that boron supplementation (3 mg/day) significantly increases serum 17-beta-estradiol concentrations by inhibiting the enzyme responsible for estradiol degradation. This can lead to additive estrogenic effects when combined with exogenous estradiol, raising the risk of thromboembolism and hormone-sensitive conditions.
Evidence
Evidence level: strong.
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 81,232 reports mentioning Estradiol. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Estradiol + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All Boron interactions → · All Estradiol interactions →
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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.