Is Boron Safe with Warfarin?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Inform your anticoagulation clinic if you are taking boron supplements. Avoid high-dose boron (above 3 mg/day) while on warfarin. Monitor INR regularly and watch for bleeding signs.
Why this interaction occurs
Boron at supplemental doses can influence estrogen and testosterone metabolism by inhibiting steroid hydroxylation enzymes. Since sex hormones affect coagulation factor synthesis and fibrinolytic activity, boron-mediated hormonal shifts may indirectly alter warfarin response.
Evidence
Evidence level: limited.
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 134,328 reports mentioning Warfarin. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Warfarin + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All Boron interactions → · All Warfarin interactions →
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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.