Is Calcium Safe with Metoprolol?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Take Metoprolol and calcium supplements at least 2 hours apart to prevent reduced drug effectiveness. Do not adjust your Metoprolol dose without physician guidance.
Why this interaction occurs
Calcium can bind to Metoprolol in the gastrointestinal tract, potentially reducing its absorption and peak plasma concentrations, which may compromise blood pressure and heart rate control.
Evidence
Evidence level: limited.
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 330,477 reports mentioning Metoprolol. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Metoprolol + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All Calcium interactions → · All Metoprolol interactions →
Already checked this one — check your whole list
Educational only — not medical advice.
Always confirm with your doctor or pharmacist.