Is Magnesium Safe with Metoprolol?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Avoid high-dose magnesium supplements without medical advice. Monitor heart rate and blood pressure. Report bradycardia symptoms such as unusual fatigue or fainting.
Why this interaction occurs
Magnesium acts as a natural calcium channel blocker and has antiarrhythmic properties. Combined with Metoprolol, it may cause additive slowing of heart rate (bradycardia) and enhanced blood pressure reduction.
Evidence
Evidence level: moderate.
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 330,477 reports mentioning Metoprolol. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Metoprolol + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All Magnesium interactions → · All Metoprolol interactions →
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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.